Purinergic facilitation of ATP-sensitive potassium current in rat ventricular myocytes
نویسندگان
چکیده
منابع مشابه
Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes.
1. The modulation of 4-aminopyridine sensitive transient outward potassium current (4-AP I(to)) by neuropeptide Y (NPY) (100 nM) in rat ventricular myocytes was examined using the whole cell voltage-clamp technique. 2. Continuous exposure to NPY (100 nM) for 3 - 6 h significantly increased 4-AP I(to) density. The stimulation of 4-AP I(to) density by NPY was concentration-dependent (EC(50)=10 nM...
متن کاملFormulation of ATP sensitive K+ Current and Action Potential Shape in Models of Human Ventricular Myocytes
The contribution of the ATP-sensitive ( ) current to the action potential is an important component of cardiac ischaemia. The purpose of this study was to investigate how the formulation of influences action potential shape and duration in the Ten TusscherPanfilov 2006 model of human ventricular myocytes. We compared four different formulations, which were inserted in the epicardial variant of ...
متن کاملEffect of extracellular ATP on the Na+ current in rat ventricular myocytes.
Extracellular ATP concentration can rise because of its release by nerve terminals and by damaged cells during ischemia. After the activation of P2-purinergic receptors, ATP induces a positive inotropic effect and increases the L-type Ca2+ current via activation of a Gs protein but without cAMP production. In addition, ATP shifts the voltage characteristics of Ca2+ current toward hyperpolarized...
متن کاملDelayed rectifier potassium current in undiseased human ventricular myocytes.
OBJECTIVE The purpose of the study was to investigate the properties of the delayed rectifier potassium current (IK) in myocytes isolated from undiseased human left ventricles. METHODS The whole-cell configuration of the patch-clamp technique was applied in 28 left ventricular myocytes from 13 hearts at 35 degrees C. RESULTS An E-4031 sensitive tail current identified the rapid component of...
متن کاملDual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes.
Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp techniqu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1997
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0700960